[2] This was the first election to take place after redistricting based on the 2020 United States census.

Following a voter-passed constitutional amendment in 2018, the state legislature no longer creates legislative and congressional districts and was replaced by Michigan's Independent Citizens Redistricting Commission, a 13-member bipartisan committee.

[3] Under the Michigan Constitution, state representatives and senators are limited to twelve years combined in either chamber of the legislature, after voters approved on November 8 a constitutional amendment that revised term limits.

[5] The following members are prevented by previous term limits from seeking re-election to the Senate in 2022.

This list does not include members that are eligible for re-election, but chose instead to seek other office or voluntarily retire.