[4] The 67 members of the Senate were elected from single-member districts via first-past-the-post voting for four-year terms.

Contested nominations of recognized major parties (DFL, Grassroots–Legalize Cannabis, Legal Marijuana Now, and Republican) for each district were determined by an open primary election.

Write-in candidates had to file a request with the Secretary of State's office for votes for them to be counted.

[5] Due to the 2020 United States Census, the law required redistricting to occur before February 15, 2022, in order to give candidates ample notice before the legislative filing window in late May.

Historically, the legislature has often been unable to agree on redistricting, leading to a court decision on the issue.