Incumbent Democratic governor Steve Sisolak ran for re-election to a second term, but lost in the general election to Republican Joe Lombardo, the Clark County Sheriff.

This was largely due to Lombardo's stronger performance in Clark, his home county; Sisolak's previous opponent, Adam Laxalt, lost the county by 13.3% there, while Lombardo only lost by 5.7%, a significant gain.

[3] Amid a slate of failed gubernatorial pickup attempts, this was the only governorship Republicans flipped in the 2022 elections, as well as the only state governorship to flip to the party that did not carry that state in the 2020 presidential election.

This was also the first time since Pat Quinn's defeat in the 2014 Illinois gubernatorial election that an incumbent Democratic governor lost re-election in any state.

Guy Nohra P  Participant   A  Absent   N  Non-invitee   I  Invitee  W  Withdrawn Despite losing re-election, Sisolak won three of the state's four congressional districts.