The 2022 Pelham Racquet Club Pro Classic was a professional tennis tournament played on outdoor clay courts.

It was the eighteenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Pelham, Alabama, United States between 16 and 22 May 2022.

[1] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: