[3] Three of the semifinalists from the previous season (the Montreal Canadiens, New York Islanders and Vegas Golden Knights) failed to qualify for the playoffs.

In game one, Maple Leaf's forward Auston Matthews provided two goals and an assist in Jack Campbell's 24-save 5–0 shutout.

[18] In game three, Pierre Engvall provided three assists for the Maple Leafs, staving off a potential comeback from Tampa Bay and winning 5–2.

[26] Upon Hurricanes forward Nino Niederreiter's two goals and Pyotr Kochetkov's 30 saves in relief of Raanta in game two, Carolina gained 2–0 series lead by defeating Boston 5–2.

[29] In game five, Seth Jarvis scored twice and Teuvo Teravainen assisted thrice in the Hurricanes 5–1 victory, taking a 3–2 series lead in the process.

[31] Max Domi scored twice and added an assist in game seven, granting Carolina a 3–2 victory and an advancement to the second round.

In game one, although Igor Shesterkin made 79 saves for the Rangers, Penguins forward Evgeni Malkin scored for Pittsburgh at 5:58 of triple overtime to win 4–3.

[37] Chris Kreider gave the Rangers a lead late in the third period of game six, giving his team a 5–3 victory and tying the series 3–3.

[38] In game seven and the subsequent overtime, Panarin scored for New York sending the Rangers to the second round with a 4–3 victory.

[39] This marked the first time the Penguins lost a game seven on the road in franchise history after winning the previous six instances.

The Rangers also became the first team in Stanley Cup playoff history to record three consecutive comeback wins in elimination games within the same series.

[41] In game two, the Avalanche shot 51 times at Predators' goalie Connor Ingram and at 8:31 of overtime, Cale Makar scored to give Colorado a 2–1 victory.

[43] In game four, Andre Burakovsky's goal and two assists helped lift the Avalanche to a 5–3 victory, advancing to the second round.

In game one, Ville Husso made 37 saves for the Blues and David Perron scored a hat trick in St. Louis' 4–0 victory.

In game one, Calgary's defence limited the Stars' offence to 16 shots as goalie Jacob Markstrom claimed a 1–0 victory.

[51] The Stars responded with their own shutout victory in game two, scoring twice in a 2–0 affair with Jake Oettinger making 29 saves in the process.

[54] In game five, Mikael Backlund and Andrew Mangiapane each scored a goal and provided an assist in Calgary's 3–1 comeback victory.

In the extra period, Calgary forward Johnny Gaudreau scored to give the Flames a 3–2 victory and a second round advancement.

[58] Mike Smith stopped all 30 shots in game two, ending his ten-game playoff losing streak with a 6–0 shutout victory.

[59] The Oilers dominated game three, forcing Los Angeles to switch goalies and giving Evander Kane a hat trick in the process of an 8–2 rout.

[61] In game five, the Oilers came back from a two-goal deficit to tie the match; however, Kings forward Adrian Kempe's overtime goal, his second score of the affair, gave Los Angeles the 5–4 victory and a 3–2 series lead.

[74] New York shut the door on Carolina in game seven, outscoring the Hurricanes 6–2 to advance to the conference final for the first time since 2015.

St. Louis managed to tie the game again, and in the subsequent overtime period, Tyler Bozak scored to give the Blues a 5–4 victory.

The Flames who reached a 6–2 lead had that advantage disappear as the Oilers tied the game; however, two of Matthew Tkachuk's hat trick goals sealed the victory for Calgary in a 9–6 affair.

[86] During the third period, Calgary had a late goal by Blake Coleman disallowed after video review determined that the puck was kicked into the net.

[87] With the game tied at the end of the third period, both teams headed to overtime where McDavid scored to send Edmonton to the Conference final for the first time since 2006.

This was Tampa Bay's third consecutive and eighth overall semifinals/conference final since entering the league; they're the first team to accomplish this feat since the 2015 Chicago Blackhawks.

[90] In game four, Palat scored a goal and provided two assists in goalie Andrei Vasilevskiy's 34 save performance to defeat New York 4–1 and tie the series 2–2.

[92] In game six, the captain Steven Stamkos scored twice to give the Lightning a 2–1 victory and a trip to the Stanley Cup Finals for the third consecutive season.

[106][107] With the NBA Conference Finals occurring at the same time with the Stanley Cup second round this year, ESPN ended up being the de facto exclusive broadcaster for the Carolina–NY Rangers and Calgary–Edmonton series, and TNT doing the same for the Florida–Tampa Bay and Colorado–St.