Liudmila Samsonova defeated Zheng Qinwen in the final, 7–5, 7–5 to win the singles tennis title at the 2022 Pan Pacific Open.

She did not drop a set en route to her third title of the season.

By reaching her first WTA Tour final as a 19-year-old, Zheng became the first Chinese teenager to contest a WTA singles final.

[1] Naomi Osaka was the defending champion from when the event was last held in 2019,[2] but withdrew from her second round match against Beatriz Haddad Maia.

[3] The top four seeds received a bye into the second round.