Barbora Krejčíková and Kateřina Siniaková defeated Caty McNally and Taylor Townsend in the final, 3–6, 7–5, 6–1 to win the women's doubles tennis title at the 2022 US Open.

Stosur partnered Latisha Chan, but lost to Miyu Kato and Aldila Sutjiadi in the first round.

Zhang partnered Marta Kostyuk, but lost to Desirae Krawczyk and Demi Schuurs in the third round.

Coco Gauff, Elise Mertens, Jeļena Ostapenko and Giuliana Olmos were also in contention for the top ranking.

[4] Lyudmyla Kichenok and Ostapenko defeated Panna Udvardy and Tamara Zidanšek in the first round in the first women's doubles main-draw 10-point tie-break at US Open.