Incumbent Republican Rand Paul won re-election to a third term, defeating Democratic nominee Charles Booker with 61.8% of the vote.

Representatives Labor unions Organizations Individuals Although Paul had initially pledged to serve only one term,[33] he later reversed this stance and ran for re-election.

[34] In both 2010 and 2016, he faced tight races, even as these years were generally unfavorable for the Democratic Party and Kentucky's conservative partisan lean.

Paul had gained a reputation as one of the most libertarian senators and often breaks with his party despite still holding conservative views on most issues.

[37] Booker positioned himself as a progressive populist, advocating for abortion rights, Universal Basic Income, Medicare for All, and a Green New Deal.

However, due to lower voter turnout, he underperformed compared to Trump's 2020 performance in the state by 2 points and received a slightly smaller percentage of the vote.