Incumbent Democratic senator Catherine Cortez Masto won re-election to a second term, narrowly defeating Republican challenger Adam Laxalt.

[1] Nevada's election results were slowed due to state law that allowed voters to submit mail-in ballots until November 12, and allowed voters to fix clerical problems in their mail-in ballots until November 14, 2022.

The incumbent Democrat's improvements in Washoe compared to 2016 proved to be decisive, as her victory margin there was slightly larger than in Nevada as a whole.

Laxalt won by landslide margins in Nevada's rural counties, but they are lightly populated and cast less than 16% of the total vote.

In the end, Cortez Masto's victories in the state's two largest counties gave her too large a lead for Laxalt to overcome in rural Nevada.