[b][3] They beat the Minnesota Twins in four games in the ALDS to reach the ALCS for the seventh consecutive season, a continued American League record in LCS appearance streak.

In the bottom of the tenth inning, reliever Ryne Stanek (1–1) lost control with two walks and two wild pitches, setting up Kyle Farmer's walk-off single that produced a 3–2 Twins victory.

Home runs by Alvarez (grand slam) and Peña provided all of Houston's scoring; however, Farmer, Christian Vázquez, and Byron Buxton each had key hits for the Twins as they held for a 9–6 win.

José Urquidy (1–2) allowed home runs to Matt Chapman and Vladimir Guerrero Jr.[102] In the series finale, Luis García (1–2) earned his first win of the season with nine strikeouts over seven innings.

Starter Framber Valdez (2–2) collected his fourth straight quality start despite allowing eight hits and two home runs, getting the Braves lineup to go 0-for-5 with runners in scoring position.

Rookie Taj Bradley (3–0) won the third of his first three major league starts and shortstop Wander Franco had four hits and an impressive barehanded catch of a Martín Maldonado fly ball in foul territory.

[107] Behind six masterful shutout innings from starter Luis García (2–2), the Astros won the middle game of the series while halting the Rays' home winning streak.

[118] May 5–7 at Seattle Mariners: SEA won series 2–1 On May 5, 2023, it was announced by Astros General Manager Dana Brown that RHP Luis Garcia would be having a season-ending ulnar collateral ligament reconstruction (Tommy John surgery).

[122][123] Phil Maton and Héctor Neris both recorded holds for Houston, and Rafael Montero (0–1) took the loss for the Astros, pitching 0.2 innings, striking out 1, while allowing 4 runs on 3 hits and 1 BB.

[158] In the sixth inning, Jake Meyers made a running catch of an Owen Miller fly ball at the warning track with a runner on base to help preserve a 2–1 Astros lead.

[161] May 26–28 at Oakland Athletics: HOU won series, 3–0 Rookie starter Hunter Brown (5–1) established a new career-high 10 batters struck out on May 26 while retiring 16 consecutive over seven strong innings to lead the Astros to a 5–2 win.

Minnesota dominated the Astros through the first 7 innings, leading 8–0 going into the bottom of the 8th, where Jake Meyers and Yainer Díaz hit back-to-back home runs, cutting the deficit to 8–2, which would end up being the final score.

Texas scored multiple runs in each of the third, fourth, and fifth innings off Astros starter Cristian Javier, who registered his fifth consecutive no-decision since winning five games in a row.

Phil Maton registered his first save since 2017 after freezing an Angels' rally, including Tucker's outstretched, game-ending catch of a Matt Thaiss sinking line drive.

The Astros overcame a 7–3 deficit in the seventh inning through hitting five home runs over the final three frames, including Bregman's, Tucker's, two from Chas McCormick, and one from Jake Meyers.

[244] On July 25, Kyle Tucker and Martín Maldonado homered, rookie starter J. P. France allowed five hits and two walks over seven solid innings to lead the Astros to a 4–3 win and move to a game behind Texas.

García hit his grand slam in a seven-run fifth inning and he and Marcus Semien exchanged words with Maldonado as they crossed home plate A benches-clearing scrum ensued though no punches were thrown.

[247] In the middle game, Jeremy Peña collected a career-best four RBI, and Yainer Díaz and José Abreu both added three to lead the Houston Astros to had their highest-scoring output of the season in a 17–4 win over Tampa Bay.

The Astros were stymied by Cleveland starter Noah Syndergaard, who allowed two hits and one run over 5+1⁄3 innings until a Jeremy Peña line drive struck his lower right and led to his removal from the game.

Verlander anchored the rotation during the Astros' six consecutive ALCS appearances from 2017 to 2022, including two World Series championships, while winning two Cy Young Awards and establishing numerous team records.

[259] J. P. France (8–3) made his first career relief appearance, allowing an unearned run in 3+1⁄2 innings to earn the win, and Bryan Abreu worked the ninth to complete his fourth save of the season.

[268] José Urquidy tossed a bounceback 5 innings in the last game of the series, striking out a season high 7 and allowing 1 run, three hits, and no walks as the Angels triumphed, 2–1.

[277] August 28–30 at Boston Red Sox: HOU won series, 3–0 Jose Altuve's cycle highlights club hitting record and first-ever sweep at Fenway.

[285] In the finale, Domínguez hit a tie-breaking three-run home in the sixth inning to lead a 6–1 Yankees win and series sweep of the Astros at Minute Maid Park.

[287] Reliever Ryne Stanek, working the bottom of the ninth to close out the game for Houston, faced just two batters as he suffered what appeared to be a serious ankle injury as he covered first base on a ground ball.

He posted a 2–0 record with a 0.69 ERA and 13 strikeouts over 13 IP, both in crucial outings against Seattle and Arizona during the Astros' final road trip that were instrumental in winning the AL West division title.

In the fourth inning, Thielbar, in relief of Ryan, yielded a single to Alvarez before allowing a two-run home run to José Abreu, giving the Astros a 3–1 lead.

Pressly struck out the side in the ninth for his second save of the series; he froze Max Kepler with a full-count fastball to end the contest with Correa waiting in the on-deck circle.

The Astros got four runs off three homers, two from Yordan Alvarez, Alex Bregman and an RBI double by Michael Brantley capped the scoring for the game as the Rangers took a 2–0 lead in the series with a 5–4 victory.

As the series shifted to Arlington for Game 3, the Astros sent out right hander Cristian Javier to the mound, while the Rangers countered with trade deadline acquisition Max Scherzer.