The Astros' pitching staff produced a record-setting August and threw three additional no-hit bids of 7+2⁄3 innings or more,[a] including one by starting pitcher Spencer Arrighetti, who was named AL Rookie of the Month.

However, right fielder Juan Soto delivered an accurate throw to home plate that allowed catcher Jose Trevino tag out Dubón to preserve the Yankees' lead and eventual victory.

[34] With Framber Valdez being skipped from making his start on April 8 due elbow soreness, Blair Henley made major league debut versus the Rangers.

[36] On April 10, Spencer Arrighetti made his major league debut for the Astros, as the starting pitcher versus the Kansas City Royals at Kauffman Stadium.

In the tenth, Caratini's walk-off, pinch hit home run in the 10th inning secured a 10–9 final to give the Astros (10–19) their first three-game winning streak of the season.

The late-game heroics followed Ronel Blanco's shortest outing of the season to date, who, after having completed the third inning, was ejected by umpire Laz Díaz during a routine foreign substance check.

[51] On May 16, Joey Loperfido hit his first major league home run and Cristian Javier (3–1) hurled six scoreless innings to lead an Astros' 8–1 win and finish a four-game sweep of Oakland.

Verlander (3–2) struck out Abraham Toro to pass Hall of Famer Greg Maddux (3,371) for 10th place on the all-time strikeout list, finishing the outing with 3,377, and won the 260th game of his career.

[55] Cristian Javier made 7 starts for the Astros and pitched 34+2⁄3 innings before it was announced on June 5 that he would undergo UCL reconstruction (Tommy John surgery), ending his season prematurely.

[61] Following a 2–0 shutout defeat to the Chicago White Sox in a series opener on June 18, the Astros' record was 33–40, distancing them 10 games from the Seattle Mariners for the AL West lead, their largest deficit of the season.

[63] In the series finale, Yordan Alvarez drove in two runs—including a home run—and Alex Bregman collected three hits and a run scored to key the Astros' 5–3 win and take 2 of 3 from the White Sox.

Bryan King and Luis Contreras both made their major league debut for the Astros, successively pitching one scoreless inning each in the eighth and ninth.

[70] On July 3, Altuve stroked a tie-breaking single in a four-run seventh inning Alvarez homered for a third consecutive game, doubled twice and also scored via an intentional base on balls.

[73] Behind six scoreless innings from Hunter Brown on July 19, the Astros (51–46) defeated the Seattle Mariners (52–47), 3–0, to take the AL West lead by a percentage point and for the first time on the season.

[45] With this win, the Astros evaporated a 10-game deficit to the then-first place Mariners in a span of 24 games, which was the quickest that large of a lead was eliminated in major league history, per the ESB.

[77] On July 30, the Astros acquired starting pitcher Yusei Kikuchi from the Toronto Blue Jays in a trade for rookies Jake Bloss and Joey Loperfido and minor league prospect Will Wagner.

[84] On August 3, outfielder Pedro León made his major league debut, collected a single versus Rays started Zack Littell in first at bat, and was thrown out by center fielder Jonny DeLuca attempting to stretch it into a double.

Astros starter Spencer Arrighetti (4–10) struck out 12 of 23 batters faced while allowing the only run of the game over six innings to establish a new career-high in strikeouts as well as the season-high for the staff to that point.

[89] On August 9, Jose Altuve hit his 224th career home run to pass Jimmy Wynn for fourth place all-time in Astros' history, which tied the game and catalyzed an 8–4 victory against the Boston Red Sox.

The pair combined to lead the Astros to 5 wins over 6 games over Boston and Texas; Bregman batted .444, 1.389 OPS, three doubles, three home runs, three walks, and six RBI.

[95] The Astros overcame four errors on August 19 when Yainer Díaz hit his first career walk-off home run to secure a 5–4 victory over the Red Sox and win for the 11th time in 12 games.

[96] On August 21, Justin Verlander (3–3) returned to the mound for his first major league start since June 9, pitched five innings and surrendered two runs as the Houston dropped the series finale to the Boston Red Sox, 4–1.

Yuli Gurriel—the 2021 AL batting champion and Gold Glover and a key member of the Astros' playoff runs from 2017–22—made his 2024 debut at Minute Maid Park as the Royals' designated hitter, and had an RBI single in the sixth inning versus Tayler Scott.

[108] On September 6, Alvarez hit a pair of three-run home runs and Framber Valdez (14–6) hurled seven two-hit shutout innings against the Arizona Diamondbacks to lead an 8–0 win over the major leagues' top-scoring offense.

Led by Yordan Alvarez and Kyle Tucker amassing four hits and a home run apiece, starter Ronel Blanco's hurled a sublime six-inning effort.

A wild pitch in the top of the 8th inning allowed Kerry Carpenter to score and tie the contest 2–2, accounting for Pressly's first career blown save in the postseason after having converted each of his first 14 opportunities.

[128] Infielders Outfielders Coaches With the 28th slot in the MLB draft order, the Astros selected catcher Walker Janek from Sam Houston State University for their first-round pick.

[131] The Astros forfeited their second-round selection in this year's draft as a result of signing free agent Josh Hader during the prior offseason, who had declined a qualifying offer from the San Diego Padres.

Pedro León and Trey Cabbage hit back-to-back home runs in the first inning for Sugar Land, and Cooper Hummel added a run-scoring double.

Miguel Ullola shut out Reno over four innings, and Logan VanWey, Forrest Whitley, Luis Contreras and Wander Suero (save credited) tossed a combined 3+2⁄3 scoreless frames.