The 2nd arrondissement of Lyon (French: 2e arrondissement de Lyon) is one of the nine arrondissements of the City of Lyon.

The first five arrondissements of Lyon were created by the Decree of March 24, 1852, which included the 2nd arrondissement.

The 2nd arrondissement is the most commercial and most lively ones of Lyon.

The districts (quarters) of the 2nd arrondissement are : This arrondissement is served by metro and tram lines of TCL network: The 2nd arrondissement is also served by Lyon-Perrache station, the second most important railway station in Lyon.