3-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is a chemical compound which is used commercially as an intermediate to seven fungicides which act by inhibition of succinate dehydrogenase (SDHI).
Inhibition of succinate dehydrogenase, the complex II in the mitochondrial respiration chain, has been known as a fungicidal mechanism of action since the first examples were marketed in the 1960s.
[2][3] By 2016, at least 18 examples were developed by crop protection companies, with the market leader being boscalid, owing to its broad spectrum of fungal species controlled.
[6] This group of pyrazole carboxamide fungicides are very effective against major crop pests such as Alternaria species, including early blight of tomato and potato.
[2]: 416–8 [12] However, none display commercial levels of activity against oomycetes, fungal-related organisms which include important diseases like Phytophthora infestans, late blight of potato.