50 Street is the designated name of two major arterial roads in east Edmonton, Alberta.

Separated by the North Saskatchewan River, it is mostly straight, and runs the entire south-north length of Edmonton as well as the suburb of Beaumont.

The Yellowhead Trail and 50 Street junction is the start of Highway 15, it then goes north to Manning Drive, which it follows from there.

The northside section of 50 Street is presently segmented by the developing community of Cy Becker with grading in place for a future interchange at Anthony Henday Drive; however, there is no timeline for construction.

List of neighbourhoods 50 Street runs through, in order from south to north.