Together these subunits are composed of 4 rRNA species and approximately 80 structurally distinct proteins.

This gene encodes a ribosomal protein that is a component of the 60S subunit.

The protein may be one of the target molecules involved in mediating growth inhibition by interferon.

In yeast, the corresponding protein binds to a specific site on the 26S rRNA.

[6] L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.