Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins.

This gene encodes a ribosomal protein that is a component of the 60S subunit.

Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter.

Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist.

As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.