Acetonedicarboxylic acid, 3-oxoglutaric acid or β-ketoglutaric acid is a simple dicarboxylic acid with the formula O=C(CH2CO2H)2. β-Ketoglutarate does not have the biological activity exhibited by α-ketoglutarate.

[2] Acetonedicarboxylic acid can also be prepared by decarboxylation of citric acid in fuming sulfuric acid:[3] Acetonedicarboxylic acid and its esters such as dimethylacetonedicarboxylate are primarily used as building blocks in the synthesis of heterocyclic rings[4] and in the Weiss–Cook reaction.

[5] Acetonedicarboxylic acid is well known to be used in the Robinson tropinone synthesis.

The presence of β-ketoglutaric acid in human urine is diagnostic for the harmful gut flora such as Candida albicans.

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