[3] It has no notable off-flavors when compared to sucrose and tastes sweet a bit longer than aspartame and is chemically more stable.

[2] Advantame can be used as a table top sweetener and in certain bubblegums, flavored drinks, milk products, jams and confectionery among other things.

[4] In 2014, FDA approved advantame as a non-nutritive sweetener and flavor enhancer within United States in foods generally, except meat and poultry.

HMPA is selectively hydrogenated with palladium on aluminium oxide and platinum on carbon in one step to advantame in methanol with aspartame.

[2] Advantame as a dry powder degrades very slowly at 25 °C and 60% relative humidity and can last for years under such conditions.

Unlike aspartame, advantame doesn't form a diketopiperazine via intra-molecular cyclization due to steric hindrance by the vanillyl group.

Advantame is poorly absorbed, rapidly metabolized and only small amounts of it and its metabolites can be detected in blood shortly after ingestion.

[1] 52% of the ingested dose is excreted in feces as de-esterified advantame and 30% as N-(3-(3-hydroxy-4-methoxyphenyl))propyl-L-aspartic acid and as an equivalent molar amount of phenylalanine.

1% of the ingested dose is excreted in urine as the aforementioned aspartic acid analog, 1.9% as 5-(3-aminopropyl)-2-methoxyphenyl and 2.3% as de-esterified advantame.