[3] Akron Children’s operates 7 regional health centers to provide convenient access to pediatric primary care, specialties and rehabilitative services.

[8] In 2019 it was announced that Akron Children’s Hospital and the Cleveland Clinic would be expanding the pediatric and adult congenital heart program that was started 2014.

[10] Akron Children's offers a full range of services to its 25-county region, including well visits and trauma and intensive care to treatment of rare and serious childhood disorders.

Services based in the Mahoning Valley include a 33-bed neonatal special care nursery; child advocacy, community outreach and education center; and subspecialty practices for cardiology, orthopedics, nephrology, neurology, rheumatology, pulmonology and genetics.

Akron Children's Hospital has earned the Gold Seal of Approval from the Joint Commission[13] and Magnet Recognition Status[14] from the American Nurses Credentialing Center.

In November 2013, the hospital went to court to prevent an 11-year-old Amish leukemia patient and her parents from making treatment decisions,[15] when the patient chose to discontinue a second round of chemotherapy after it made her "extremely ill." An appeals court ruled that the state's duty to protect the child's well-being outweighed the parents' beliefs and convictions, and an attorney who was also a nurse, was given limited guardianship of the child.

"[17] The girl's father told the Associated Press that the family does not oppose modern medicine nor did they make their decision based on religious beliefs.

[21][22] Children's is affiliated with Northeast Ohio Medical University (NEOMED) in Rootstown as one of the school's nine major hospital associations.

The Akron Cooperative Medical Laboratory Science Program (ACMLSP) is a joint educational effort with Akron Children's Hospital, Summa Health (5 locations), and Aultman Health Foundation (2 locations) that offers didactic and clinical education in medical laboratory science.