A flu epidemic in 1920 resulted in many deaths of patients while being transported to the nearest hospital in nearby Cleveland.

After several expansions and a name change to Southwest General Hospital, the current site ran out of room to expand.

In 1973 the local communities of Berea, Brook Park, Olmsted Falls, Olmsted Township, Strongsville, and Middleburg Heights passed tax levies to support the building of a new 235-bed facility nearly a mile down the road from the original location in Middleburg Heights.

[5] Southwest General built an addition to house their own branch of University Hospitals Ireland Cancer Center.

[6] This allows Southwest General to offer cancer treatment on-site, as well as providing access to clinical trials.