Founded in 1964, it is the flagship hospital of Kettering Health, and is directly affiliated with the Seventh-day Adventist Church.

During the polio epidemic in the 1950s, they were inspired by the care given at Hinsdale Hospital, which would play a vital role in the foundation of Kettering Medical Center.

Following the death of his father in 1958, the younger Ketterings moved from Illinois back to Dayton to help manage family affairs.

Health care was a primary focus of Charles Kettering, so Eugene and Virginia led efforts to open a local area hospital in his honor.

In 1964, Charles F. Kettering Memorial Hospital opened under the leadership of the Seventh-day Adventist Church.