It stretches from Edmonton through Wainwright to the Alberta–Saskatchewan border, running parallel to the more northern Highway 16.

[3] It travels east for 9 km (5.6 mi) along Whitemud Drive through neighbourhoods of southeast Edmonton until reaching the Anthony Henday Drive ring road, with which it is concurrent for 2 km (1.2 mi).

It continues east toward Tofield where it bends southeast, paralleling the main line of the Canadian National Railway, and passes through Ryley, Poe, Holden, and Bruce before intersecting Highway 36 (Veterans Memorial Highway) in Viking.

The route then travels due east and intersects Highway 17 to enter Saskatchewan.

[8] From west to east:[9] There are three former auxiliary routes of Highway 14 located in the Edmonton area.