[2] Amoroso has collaborated and worked with notable Italian artists, including Loredana Bertè, Elisa, Emma Marrone, J-Ax, Fedez, Tiziano Ferro, Francesco Renga and Fiorella Mannoia.

She also acted in Io che amo solo te by Marco Ponti in 2015 and she co-hosted with Gianni Morandi the TV program Grazie a tutti in 2009.

[3] In June 2007 she participated in a contest, Fiori di Pesco, singing the song Amor mio, and placed first among the competitors, and was rewarded by Mogol.

[5] On 5 October 2008, Amoroso passed the audition for the eighth season of Amici di Maria De Filippi, singing the Alicia Keys single, "If I Ain't Got You".

[9] After presenting the song during the final of Amici di Maria De Filippi, Alessandra released her first single, "Stupida" on 27 March 2009.

[11] On 6 June 2009, in Verona, Alessandra received two Wind Music Award for the sales of Stupida and the compilation Scialla, both certified multiplatinum.

[14][15][16][17] On 21 June 2009, she performed at the concert "Amiche per l’abruzzo", organized by Laura Pausini, at the San Siro stadium in Milan.

[22] On 31 July 2009, during the Stupida Tour, Amoroso officially announced the release date of her debut studio album, Senza nuvole, scheduled for 25 September 2009.

[28] In December 2009 Amoroso recorded, along with other artists, including J Ax and Marracash, a Christmas jingle for Radio Deejay, entitled "Questo natale".

The album's release date, 28 September 2010, was announced on 30 August on Sony's official website,[41] consisting of thirteen songs, including two in English produced by Chico Bennett, who has previously worked with artists such as Madonna and Destiny's Child.

In early 2013, Amoroso performed at numerous events and television programs, announcing in the summer the release of her third studio album, produced by Tiziano Ferro.

[49] On 22 January 2015, the singer announced the release of the book A mio modo vi amo (In My Way I Love You) on 10 March, which she wrote and which collects various short stories and thoughts written by her fans.

[52] On 15 September 2015, the singer's first Spanish-language single was released entitled "Grito y no Me Escuchas", a translated version of the song "Urlo e non mi senti".

In November, Alessandra embarked on a promotional tour through Latin America, with stops including Mexico, Argentina and Costa Rica.

The album was produced by Michele Canova and Andrea Rigonat, and features numerous writers, including Elisa, Tiromancino, Dario Faini and Tiziano Ferro.

[63] On 5 October 2018, Alessandra Amoroso published her sixth studio album 10, a title chosen to celebrate the singer's ten years as a solo artist, anticipated by the singles "La stessa" and "Trova un modo".

[67] The following month, she was a guest at the 69th Sanremo Music Festival, receiving a standing ovation from the audience thanks to her rendition of "Io che non vivo (senza te)" with Claudio Baglioni.

[87] In 2018, Amoroso founded "Big Family Onlus," a nonprofit association to support the singer's humanitarian aid campaigns.

[94] Amoroso also worked with Save the Children,[95] Caritas,[96] Médecins Sans Frontières,[97] and AIRC Foundation for Cancer Research in Italy.

[101][102] On 21 June 2009, Amoroso performed at the "Amiche per l'Abruzzo", a charity initiative concert created after the L'Aquila earthquake, alongside 102 Italian female singers, including Laura Pausini, Fiorella Mannoia, Gianna Nannini, Elisa, Emma Marrone, Giorgia, Arisa, Carmen Consoli and Raffaella Carrà.

[103] In 2020, the benefit concert event "Una, Nessuna, Centomila" was announced, promoted by the singer herself together with Laura Pausini, Fiorella Mannoia, Gianna Nannini, Elisa, Emma Marrone and Giorgia, to combat gender inequality and violence against women in Italy.

[105] Alessandra Amoroso has repeatedly stated that her favorite kinds of music are the black, soul, R&B and gospel, which represent the timbre of the singer.