After being part of two bands, Elaphe Guttata and leNoire (formerly Malvasia), she rose to fame after coming in second in the tenth season of the Italian talent show Amici di Maria De Filippi (2010–2011).

After her first participation, Annalisa took part in the Sanremo Music Festival 5 more times, reaching the podium twice, in 2018 with "Il mondo prima di te" and in 2024 with "Sinceramente".

[8] She has also written songs for other artists including Gianna Nannini, Fedez, Benji & Fede [it] and collaborated with David Guetta, Boomdabash, Tedua, J-Ax, Antonello Venditti, Gianluca Grignani, Achille Lauro, Vanesa Martín, and Nomadi.

From 2015 to 2019, she presented the documentary series Tutta colpa di ... on Italia 1, focusing on the scientists Albert Einstein, Galileo Galilei, Charles Darwin, and Leonardo da Vinci.

[14] In 2011 Annalisa took part at the 10th edition of the Italian talent show Amici di Maria De Filippi where she finished second and also received the critics' prize.

[19] At the end of the same year Annalisa sang "Pirati", which featured in the Italian version of the film Ice Age: Continental Drift.

[29] On 1 April 2014, Annalisa made a guest appearance on Incredibile, the new studio album of Moreno, featuring on the song "Ferire per amare".

[36][37] On 14 December 2014, the singer was announced as a competitor of Sanremo Music Festival 2015 with the song "Una finestra tra le stelle"[38] and finished fourth.

[4] Along with the songs "Sento solo il presente" and "L'ultimo addio", "Una finestra tra le stelle" anticipated the release of the fourth album.

Annalisa also announced the first two dates of her Splende tour, on 1 April, at the Teatro Nuovo of Milan and 3 to Auditorium Parco della Musica of Rome, with pre-sales open from 26 January.

[47] Annalisa took part at the Sanremo Music Festival for the fourth time in 2018 and finished third, with the song "Il mondo prima di te" (English: The world before you).

[56] The song also reached number 1 on the Italian airplay chart, and was certified quadruple platinum in Italy for sales exceeding 400,000 copies.

The song was written in August 2021 and Annalisa described it as her 'first step into a new world', with its message of dancing to let go of paranoia and disappointment being the 'perfect musical representation of her as a person'.

[59] The track was also certified quintuple platinum in Italy, for sales exceeding 500,000 copies, making it her joint highest-selling song in the territory.

[60][61] A dance routine choreographed by Joey di Stefano became a popular trend on the app receiving millions of views and was featured alongside Annalisa's performance of "Bellissima" at the Sanremo Music Festival in February 2023.

[69] At RTL's Power Hits Estate 2023, "Mon amour" was awarded the SIAE prize for the most performed song of the summer at Italian musical events.

[61] On 25 May 2023, Annalisa released the single "Disco Paradise" in collaboration with Fedez and Articolo 31, with a sound 'ranging from old-school hip hop to radio pop'.

[72] "Disco Paradise" reached a peak of number three on the Italian singles chart and was certified quintuple platinum in Italy, for sales exceeding 500,000 copies.

[69] In June 2023, Annalisa announced the title of her upcoming eighth studio album, E poi siamo finiti nel vortice, set for release in autumn 2023.

Alongside this she announced her first arena tour, "Tutti nel vortice", which took place in April 2024 with dates in six Italian cities.

[78] On the day prior to its single release, Annalisa performed "Euforia", as well as a medley of "Bellissima", "Mon amour" and "Ragazza sola", as a guest on the Italian X Factor.

[80] On 23 November 2023, an Amazon Music Edition of E poi siamo finiti nel vortice was released, containing the original 12 tracks as well as a cover of "Christmas (Baby Please Come Home)" and an acoustic version of "Ragazza sola".

[85][17] On 5 June 2024, she released the single "Storie brevi" with Tananai, which was digitally added to E poi siamo finiti nel vortice.