Okafor was selected by the Arizona Cardinals in the fourth round of the 2013 NFL draft, and has also played for the New Orleans Saints and Kansas City Chiefs.

[4] In his freshman year, he helped Texas reach the BCS Championship Game, where he recorded one tackle in a loss to Alabama.

He finished his 2011 junior season with 46 tackles and seven quarterback sacks, and was named a first-team All-American as a defensive end by the American Football Coaches Association (AFCA).

[10] Okafor recorded his first two career sacks in Week 6 of the 2014 season against the Washington Redskins on quarterback Kirk Cousins.

[12] He ended the season playing in 13 games with 12 starts, recording 30 tackles, 8 sacks, three passes defensed and one interception.

[23] On October 24, 2020, Okafor was placed on injured reserve after suffering a hamstring injury in Week 6 and was activated on November 21, 2020.

[28] In 2020 during his time with the Chiefs, Okafor sponsored the NFL youth education program Kingdom United at Pflugerville Independent School District.

The program taught unity and diversity among students, and Okafor said “When we first started the season, we wanted to dedicate time and energy into social justice initiatives and ending systemic racism,” and that he "wouldn’t be where I’m at without the education I received there, it was a no-brainer for me to adopt them and bring the Kingdom program to every single kid in that school.” [29] In 2024, Okafor ran to be on the PfISD Board of Trustees unopposed, and was elected on May 4.

"[31] Since then, he has served on the Board and remained active in the Pflugerville community, hosting multiple book fairs and providing mentorship to students.

[32] Okafor traveled to Kenya during the 2016 offseason with former Texas and Saints teammate Kenny Vaccaro and is involved in community and fundraising efforts to construct a school in the region.