Written by Krista Vernoff and directed by Debbie Allen, the episode aired on the American Broadcasting Company (ABC) in the United States on May 17, 2018.
The episode focuses on the wedding between Alex Karev (Justin Chambers) and Jo Wilson (Camilla Luddington), where unforeseen complications arise.
Upon its original broadcast, "All of Me" was watched by 7.60 million viewers in the United States, ranking #1 in its time-slot, and earned a 1.9/8 Nielsen rating in the 18–49 demographic.
On her last day in Seattle, Arizona Robbins (Jessica Capshaw) helps Alex Karev (Justin Chambers) prepare for his wedding while they reflect on their long-standing friendship.
During this time, Arizona confides in April Kepner (Sarah Drew) and Richard Webber (James Pickens Jr.) that she is falling for Callie Torres (Sara Ramirez) again, expressing concern about the potential for disaster given their rocky history.
A drunken Andrew DeLuca (Giacomo Gianniotti) delivers a speech, reflecting his grief over Sam Bello's (Jeanine Mason) departure.
Meanwhile, Miranda Bailey (Chandra Wilson) and Ben Warren (Jason George) are among the guests who went to the wrong wedding and are the last to leave the church, just as the bride's mother collapses.
"All of Me" received widespread critical acclaim, with high praise directed towards the performances of Jessica Capshaw (Arizona Robbins) and Sarah Drew (April Kepner).