The episode focuses on Owen Hunt (McKidd) as he learns shocking news about the fate of his sister, Megan (Abigail Spencer), who had been missing in action and is the fiancée of Nathan Riggs (Martin Henderson).
Struggling with the idea of entering a new relationship after her husband Derek Shepherd's (Patrick Dempsey) death, she tells Nathan she isn't ready for him to meet her kids.
Meanwhile, Owen Hunt (Kevin McKidd) is visited by two army soldiers who deliver shocking news about his sister Megan (Abigail Spencer), who had been missing in action for years.
While Owen struggles to believe the news, Amelia takes matters into her own hands and contacts Teddy Altman (Kim Raver) to arrange Megan's transfer to Grey Sloan Memorial.
Stephanie Edwards (Jerrika Hinton), returning to work after mandated counseling sessions overseen by Eliza Minnick (Marika Domińczyk), deals with her emotional turmoil while treating patients.
However, they both end up trapped on an empty floor along with Erin, a young girl who had been wandering the hospital unattended while her frantic parents were preoccupied with her baby sister, who had nearly choked on a penny.
Alex imagines multiple scenarios of confronting Paul but ultimately chooses restraint, knowing that any rash action could land him in prison and put Jo in more danger.
"True Colors" received positive reviews from television critics, with high praise directed towards the performances of Kevin McKidd (Owen Hunt) and Jerrika Hinton (Stephanie Edwards).