Written by William Harper and directed by Rob Corn, the episode originally aired on the American Broadcasting Company (ABC) in the United States on May 14, 2015.

Amelia Shepherd (Caterina Scorsone) must come to terms with losing her brother, while Owen Hunt (Kevin McKidd) faces his own emotional challenges.

Upon its original broadcast, "You're My Home" was watched by 8.33 million viewers in the United States, ranking #1 in its time-slot, and earned a 2.3/8 Nielsen rating in the 18–49 demographic.

The episode opens with a voice-over narration from Meredith Grey (Ellen Pompeo) reflecting on the theme of the fragility and resilience of home and family.

With only five minutes to get April Kepner's (Sarah Drew) patient from the car to the operating table, Stephanie Edwards' (Jerrika Hinton) interns work together to clear a path through the hospital.

April, yearning for meaning, wants to return overseas to work in war zones, but Jackson presents her with an ultimatum: if she leaves, their marriage will not survive her absence.

Meanwhile, Richard Webber (James Pickens Jr.) informs Miranda Bailey (Chandra Wilson) that she will be nominated as the next Chief of Surgery, only to be met with resistance from Catherine Avery (Debbie Allen), sparking conflict between them.

The episode concludes with Meredith, Maggie, and Amelia "dancing it out", accompanied by Richard, Catherine, Bailey, Ben, Owen, Callie Torres (Sara Ramirez) and Jackson.

[1] "You're My Home" received positive reviews from television critics upon telecast, with high praise for the performances of Ellen Pompeo (Meredith Grey) and Caterina Scorsone (Amelia Shepherd).

TVFanatic gave a positive review, stating, "It's a satisfying ending that would actually work well for a series finale, if you don't count that last strange black-and-white shot of Meredith Grey (Ellen Pompeo) dancing.

"[6] TV Equals highlighted the emotional aspects of the episode, particularly the bond between Amelia Shepherd (Caterina Scorsone), Maggie Pierce (Kelly McCreary), and Meredith, writing, "I’m not exactly a fan of doctors breaking out in tears in the operating room, but I liked how Amelia and Maggie’s conflicts culminated in a nice moment of sisterly bonding and dancing it off with Meredith at the end.

Online also gave a positive review, adding, "Tonight's finale felt like any other standard Grey's Anatomy mid-season episode... until the last 5 minutes, when she managed to slip in 1 scene that totally wrecked us all over again.