Written by William Harper and directed by Debbie Allen, the episode aired on the American Broadcasting Company (ABC) in the United States on May 19, 2016.

The episode centers around the wedding of Owen Hunt (Kevin McKidd) and Amelia Shepherd (Caterina Scorsone), where tensions run high.

Meanwhile, Jo Wilson (Camilla Luddington) confesses a long-held secret to Alex Karev (Justin Chambers), while Arizona Robbins (Jessica Capshaw) and Callie Torres (Sara Ramirez) navigate the emotional aftermath of their custody battle.

Upon its original broadcast, "Family Affair" was watched by 8.19 million viewers in the United States, ranking #2 in its time-slot, and earned a 2.3/9 Nielsen rating in the 18–49 demographic.

The episode opens with a voice-over narration from Meredith Grey (Ellen Pompeo) about questioning the limits of love and embracing the courage to believe in its boundless potential.

Meanwhile, April Kepner (Sarah Drew), who is serving as Owen's best man, realizes she has forgotten the wedding rings and rushes back to Meredith's house with Ben Warren (Jason George) to retrieve them.

[1] Their character's storyline involved a custody battle with ex-wife Arizona Robbins, played by Jessica Capshaw, which culminated in Callie's decision to move to New York City from Seattle.

[7] "Family Affair" received positive reviews from television critics upon telecast, with praise directed towards the performances of Sara Ramirez (Callie Torres) and Jessica Capshaw (Arizona Robbins).