[1] Although announced as departing during the season, Jake Borelli and Midori Francis retain their series regular status.

Among these were two of three original cast members — Chandra Wilson and James Pickens Jr. — as well as others, including Kevin McKidd, Kim Raver, Caterina Scorsone, and Camilla Luddington.

[19] To further lower production costs, Jake Borelli who portrays Dr. Levi Schmitt and who joined the show in season 14, was announced to be departing the series.

[22] Former series regular Scott Speedman is also set to see an increased presence in the season as Grey's love interest, Dr. Nick Marsh.

[27] On January 8, 2025, it was announced that production was temporarily suspended due to the ongoing wildfires in the Southern California region, where the show is filmed.