Alsheim is mentioned in the Wormser wall-building ordinance from around 900 as one of the places that shared responsibility for maintaining the city wall of Worms.

The village, along with the hamlet of Hangen-Wahlheim, lies amidst vineyards at the foot of the Rhenish-Hessian Rhine terraces between Mainz and Worms.

Favoured as it is by its central location between the Frankfurt Rhine Main Region and the Rhine-Neckar conurbations, Alsheim has for a long time been growing into a markedly residential community.

With more than 700 ha of vineyard, Alsheim is one of Rhenish Hesse's most important winegrowing centres in Germany's biggest wine region.

In the heart of Alsheim can be found a railway station, from which travellers can ride VRN and DB trains directly to Worms and Mainz.