The Altarpiece of the Halberd is an oil-on-canvas painting created ca.1539 by the Italian High Renaissance painter Lorenzo Lotto.

The work was seen by the art biographer Giorgio Vasari in the church of Sant'Agostino in Ancona, where Lotto had fled in reply to the hostility received in Venice.

The monumental composition is taken directly from the tradition of Holy Conversations in the Venetian School, inaugurated by Antonello da Messina's San Cassiano Altarpiece.

It shows the Madonna and Child on a high throne, with two angels holding the crown (a 15th-century Flemish painting element also in use in Italy).

The work is characterized by a certain archaic style, explainable by the relatively provincial commissioners and the late stage of his career.