The Portrait of Andrea Odoni is an oil-on-canvas painting by the Italian High Renaissance painter Lorenzo Lotto dated 1527, now in the Royal Collection of the United Kingdom.

[1] The style is typical of Lotto's Venetian period, with denser tones, a softer chromatic range and atmospheric effects at the boundaries.

The portrait hung in Odoni's bedroom, alongside paintings by Titian and Palma Vecchio and a reclining nude by Girolamo Savoldo.

[4] The horizontal format, with which Lotto had already experimented for portraits of couples, was adopted here for a single subject, a merchant Renaissance humanist portrayed as though among his collection of marbles from Classical antiquity.

It later passed to Lucas van Uffelen, probably by 1623, then to Gerrit Reynst, 1639, then to the States of Holland and West Friesland for presentation to Charles II of England as part of the Dutch Gift of 1660.