The Portrait of a Gentleman with a Lion Paw is an oil-on-canvas painting by the Italian High Renaissance painter Lorenzo Lotto, dating c. 1524–1525.

The work's history can be traced from 1679, when it was listed in the collection of Archduke Leopold Wilhelm of Austria.

Neither the identity of the sitter nor the date the portrait was painted is known, although the work has been assigned to Lotto's early Venetian period, when he carried out commissions for several private patrons.

He stands in front of a rich red and a green textile background and shows us a gilt lion's paw.

His right hand, in a gesture typical of Lotto, touches his heart, showing two valuable rings.