The Portrait of Lucina Brembati is an oil-on-panel painting by the Italian High Renaissance painter Lorenzo Lotto, dating to c. 1518.

The subject was identified later, after the rebus included in it was recognized: the moon in the upper left background contains the inscription "CI", which, in Italian, translates as "CI in Luna", e.g. "LuCIna"; the Brembati coat of arms is instead contained in ring of the woman's left forefinger.

Lucina wears rich clothes with gilt ribbons and shell-shaped embroideries, as well as several jewels including a necklace of pearls, and another with a horn-shaped pendant, which at the time was used as a toothpick.

Working differently from the idealized portraits Titian and Palma the Elder had made widespread in Venice, Lotto used a more realistic approach: this is shown is details such as the asymmetric face, the weighty chin, and the sharp nose.

The dead weasel could also symbolize the defeat of a presage of disgrace for pregnant woman.