Anaerobic cellular respiration and fermentation generate ATP in very different ways, and the terms should not be treated as synonyms.
The reduced chemical compounds are oxidized by a series of respiratory integral membrane proteins with sequentially increasing reduction potentials, with the final electron acceptor being oxygen (in aerobic respiration) or another chemical substance (in anaerobic respiration).
[citation needed] Fermentation, in contrast, does not use an electrochemical gradient but instead uses only substrate-level phosphorylation to produce ATP.
[citation needed] There are two important anaerobic microbial methane formation pathways, through carbon dioxide / bicarbonate (HCO−3) reduction (respiration) or acetate fermentation.
Like mitochondria in oxygen-respiring microorganisms, some single-cellular anaerobic ciliates use denitrifying endosymbionts to gain energy.
However, uncontrolled methanogenesis in landfill sites releases large amounts of methane into the atmosphere, acting as a potent greenhouse gas.
[7] Specific types of anaerobic respiration are also critical in bioremediation, which uses microorganisms to convert toxic chemicals into less-harmful molecules to clean up contaminated beaches, aquifers, lakes, and oceans.
The reduction of chlorinated chemical pollutants, such as vinyl chloride and carbon tetrachloride, also occurs through anaerobic respiration.