[1] Andrea began his political career in 1411 as Councilor of the Republic.

Esteemed by his fellow citizens, he directed numerous diplomatic missions, including the one to make agreements with the then pope John XXIII Cossa, while in 1420 he was ambassador in Genoa.

In 1431 and 1438 he was Consul of the Mint and in 1432 Podestà of the municipalities of Segna and Campi.

However, his career was hampered by the fact that the Pazzi family belonged to the list of Magnate, noble families that were barred from public political positions due to the Ordinances of Justice of Giano della Bella.

In 1434 he allied himself with Cosimo de' Medici, who was also married to a Bardi, Contessina, and ensured that the Pazzi family was registered among the Popolari ones, so as to allow them a political career.