[7] The TEK gene, which codes for the endothelial cell tyrosine kinase receptor Tie-2, was found to contain a mutation in a case of dermal angiolymphoid hyperplasia with eosinophilia, suggesting that specific molecular changes may play a role in the pathophysiology of this condition.

[16] A clear correlation between angiolymphoid hyperplasia with eosinophilia and mycosis fungoides has not yet been documented, and this association is fairly ambiguous.

[14][15] The same monoclonal TCR gene rearrangement was found in both lesions in a patient, who had both peripheral T-cell lymphoma and angiolymphoid hyperplasia with eosinophilia.

[18] When angiolymphoid hyperplasia with eosinophilia lesions are examined under a microscope, a polymorphous vascular pattern made up of uniformly spaced linear and dotted vessels is visible over a background that ranges in color from pink to red.

[19] The preferred course of treatment is surgical excision; after being fully removed, angiolymphoid hyperplasia with eosinophilia rarely returns.