Eosinophilic fasciitis (/ˌiːəˌsɪnəˈfɪlɪk ˌfæʃiˈaɪtɪs, ˌiːoʊ-, -ˌfæsi-/[2][3]), also known as Shulman's syndrome,[4] is an inflammatory disease that affects the fascia, other connective tissues, surrounding muscles, blood vessels and nerves.

However, unlike scleroderma, eosinophilic fasciitis affects the deeper fascial layers, rather than the dermis; the characteristic and severe effects of scleroderma and systemic sclerosis, such as Raynaud's syndrome, involvement of the extremities, prominent small blood vessels (telangiectasias), and visceral changes such as swallowing problems, are absent.

[citation needed] Because the disease is rare and clinical presentations vary, a clear set of symptoms is difficult to define.

[citation needed] Most cases are idiopathic, but strenuous exercise,[6] initiation of hemodialysis,[8] infection with Borrelia burgdorferi,[9] and certain medications, such as statins, phenytoin, ramipril, and subcutaneous heparin,[10] may trigger the condition.

It remains unclear whether the condition is more common in women or men; patient numbers are small, and studies conflict in their reports of preponderance.