2FOT, 3F31, 3FB2670920740ENSG00000197694ENSMUSG00000057738Q13813P16546NM_001375310NM_001375311NM_001375312NM_001375313NM_001375314NM_001375318NM_001076554NM_001177667NM_001177668NM_001309460NM_001369325NP_001362239NP_001362240NP_001362241NP_001362242NP_001362243NP_001362247NP_001171138NP_001171139NP_001296389NP_001356254Alpha II-spectrin, also known as Spectrin alpha chain, brain is a protein that in humans is encoded by the SPTAN1 gene.

[8][21] Fourthly, a six amino acid insert in the twenty-first spectrin motif with unknown function has been reported.

In a canine model of hypothermic circulatory arrest, alpha II-spectrin breakdown products have shown to be relevant markers of neurologic injury post-cardiac surgery.

[25] Alpha II-spectrin has shown promising utility as a biomarker for brain necrosis and apoptosis in infants with congenital heart disease; breakdown products of alpha II-spectrin have been detected in the serum of neonates in the perioperative period and following open-heart surgery.

[26] Elevated protein expression of alpha II-spectrin has been detected in cerebrospinal fluid in patients with Guillain–Barré syndrome.