5773180297ENSG00000160460ENSMUSG00000011751Q9H254n/aNM_020971NM_025213NM_001199234NM_001199235NM_001199236NM_032610NP_066022NP_079489n/aSpectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a protein that in humans is encoded by the SPTBN4 gene.

[5][6] Spectrin is an actin crosslinking and molecular scaffold protein that links the cell membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles.

It is composed of two antiparallel dimers of alpha- and beta- subunits.

A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons.

Multiple transcript variants encoding different isoforms have been found for this gene.