Anne Weying first appeared in The Amazing Spider-Man #375 (March 1993), and was created by writer David Michelinie and artist Mark Bagley.

[2] She-Venom then lashed out against the men who had hurt her with such violence that Eddie was afraid for her and compelled the Venom symbiote back.

[3] Weying is later incarcerated by the police on a false charge (unrelated to Anne's previous rampage) in order to trap Venom.

Weying commits suicide after spotting Spider-Man webslinging in an older black costume at a time when the regular red and blue suit had been stolen.

During the Secret Wars storyline taking place in King James' England (which is based on the Marvel 1602 reality), Anne Weying is a "village beauty" who is brainwashed by printer's apprentice Edwin Brocc into loving with powers and potions supplied by the Enchantress.

Anne was shocked and distraught at her husband's death and eventually goes to the same church to mourn him, where her rage attracted the symbiote and transformed her into this world's version of Venom.

To counter Codex's threat towards the planet, President Eugene Thompson recruits Anne into the Sym-Soldier program, where she leads a group of symbiote heroes consisting of Peter Parker, Wade Wilson, a reformed Cletus Kasady, and Andi Benton.

[12] Anne Weying appears in films set in Sony's Spider-Man Universe, portrayed by Michelle Williams.