The college has six departments, 11 undergraduate programs/majors, and 17 graduate degree programs[1] at its main campus in the University City section of Philadelphia, one block from 30th Street Station.

[3] Drexel was cited by Forbes magazine as one of the top 25 STEM (science, technology, engineering, mathematics) schools in the country.

[4] The Material Science and Engineering depart was ranked #29 for Global Universities in 2023 by U.S. News & World Report.

Drexel foresaw the need for an institution with an emphasis on science and technology that would advance the common ideals of a just and diverse society by providing open access to higher education.

[12] Alumni from the college of engineering include astronauts Christopher Ferguson and Paul W. Richards, inventor of network packet switching Paul Baran, developers of barcode technology Bernard Silver and Norman Joseph Woodland, professor Eli Fromm, AI researcher and podcast host Lex Fridman, financier Bennett S. LeBow, and engineer David H. Geiger.