Anti-actin antibodies

Anti-actin antibodies (AAA)[1] are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.

In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage.

[2][3] In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition,[4] the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients.

[5] In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.

[6] It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.