[1] As a result, AAHA are strongly implicated in autoimmune deep vein thrombosis.
[2] This contrasts with the major, specific, activity of AAHA, defining a subset of anti-cardiolipin antibodies that specifically interacts with Apo-H.[3] AHAA only inhibits the anti-coagulation activity in the presence of Apo-H and the AAHA component of ACLA correlates with a history of frequent thrombosis.
A subset of AHAA appear to mimic the activity of lupus anticoagulant and increase Apo-H binding to phospholipids.
[citation needed] The haplotype HLA-DR4-DQ3 appears to play a role in the pathogenic AAHA production.
However, in European Americans which reflects a broad area of Europe in which the original studies were conducted only DR4(0402)-DQ8 was found, indicating that the entire haplotype is involved.