Anti-thrombin antibodies

Anti-thrombin antibodies are autoantibodies directed against thrombin that may constitute a fraction of lupus anticoagulant and are seen an increased levels in systemic lupus erythematosus.

Anti-thrombin antibodies can react with both types of thrombin in the antithrombin-thrombin complex.

[1] Antibodies (IgG) against thrombin can strongly inhibit its activity.

[3] Autoimmune anti-thrombin was also found to inhibit the binding of antithrombin III to thrombin.

[4][5] Multiple studies have shown, however, that despite autoimmune anti-thrombin thrombin inhibitory activity, these antibodies correlate with thrombotic events, so that they may also perturb the regulation of coagulatory factors.