Antigua and Barbuda competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016.

The Antigua and Barbuda Olympic Association sent the nation's largest roster to the Games for the first time since 1996.

A total of nine athletes, seven men and two women, were selected to compete only in athletics and swimming, due to the presence of the men's 4 × 100 m relay team.

[2] Being the most experienced member of the team, sprinter Daniel Bailey was appointed to carry the nation's flag for the third time in the opening ceremony.

Athletes from Antigua and Barbuda have so far achieved qualifying standards in the following athletics events (up to a maximum of 3 athletes in each event):[4][5] Antigua and Barbuda has received a Universality invitation from FINA to send two swimmers (one male and one female) to the Olympics.