Antigua and Barbuda competed at the 2019 Pan American Games in Lima, Peru from July 26 to August 11, 2019.

During the opening ceremony of the games, sailor Jalese Gordon carried the flag of the country as part of the parade of nations.

Both Priscilla Frederick and Cejhae Greene would go onto win medals in their respective events.

[8][9][10] Antigua and Barbuda received two universality spots in swimming to enter one man and one woman.

[11][12] Antigua and Barbuda received one wildcard to enter a male singles competitor.