[1] Antimony(III) sulfate was first produced in 1827 by the reaction of antimony(III) oxide and 18 molar sulfuric acid at 200 °C:[1] The concentration of the sulfuric acid is important, as a lower concentration will produce basic antimony oxides, while a higher concentration will produce antimony(III) pyrosulfate.

[1][4][5] Owing to its solubility, antimony sulfate has uses in the doping of semiconductors.

[6] It is also used for coating anodes in electrolysis and in the production of explosives and fireworks.

[4] Antimony(III) sulfate causes irritation to the skin and mucous membranes.

However, basic hydrated Sb sulfates are known as the minerals klebelsbergite[8][9] and coquandite.