[1] This inflammation has a number of possible causes, including trauma, viral or bacterial infections (notably, syphilis), and certain immune disorders and connective tissue diseases.

The initial treatment of suspected infectious aortitis is intravenous antibiotics with broad antimicrobial coverage of the most likely pathologic organisms, In contrast, immunosuppressive therapy is the primary treatment of non-infectious aortitis due to large-vessel vasculitis, and patients are ideally managed by a multi-disciplinary team that includes a rheumatologist and medical and surgical cardiovascular specialists.

Once the diagnosis of non-infectious aortitis due to GCA or Takayasu arteritis has been established, oral glucocorticoid therapy should be initiated.

[6] Frequently, adjunctive immunosuppressants, including methotrexate and azathioprine, are paired with steroids to treat refractory disease or to minimize steroid-induced adverse effects.

[7] Management includes the following treatment priorities: stop the inflammation, treat complications, prevent and monitor for re-occurrence.